scholarly journals The Embedding of Meta-tetra(Hydroxyphenyl)-Chlorin into Silica Nanoparticle Platforms for Photodynamic Therapy and Their Singlet Oxygen Production and pH-dependent Optical Properties¶

2003 ◽  
Vol 78 (6) ◽  
pp. 587 ◽  
Author(s):  
Fei Yan ◽  
Raoul Kopelman
Keyword(s):  
Optical Properties ◽  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Silica Nanoparticle ◽  
Oxygen Production ◽  
Ph Dependent

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

Assessment of the relevance of GaPc substituted with azido-polyethylene glycol chains for photodynamic therapy. Design, synthetic strategy, fluorescence, singlet oxygen generation, and pH-dependent spectroscopic behaviour

2017 ◽  
Vol 41 (18) ◽  
pp. 10027-10036 ◽  
Author(s):  
Veysel Koç ◽  
Sevinc Zehra Topal ◽  
Duygu Aydın Tekdaş ◽  
Özge Dilara Ateş ◽  
Emel Önal ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Polyethylene Glycol ◽  
Singlet Oxygen ◽  
Synthetic Route ◽  
Spectroscopic Behaviour ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Synthetic Strategy ◽  
Ph Dependent ◽  
Therapy Design

New synthetic route and PDT potential of symmetrically and asymmetrically substituted Ga(iii)Pcs with terminal azides.

The Measurement of Singlet Oxygen Production in an Experimental Tongue Cancer Model as an Indicator for Photodynamic Therapy

2013 ◽  
Vol 136 (0) ◽  
pp. 62-69
Author(s):  
Ying-Ying Wu ◽  
Toru Hirano ◽  
Junko Yamamoto ◽  
Guang-Wu Huang ◽  
Seiji Yamamoto ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Tongue Cancer ◽  
Oxygen Production ◽  
Cancer Model

scholarly journals Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma.

2001 ◽  
Vol 48 (1) ◽  
pp. 277-282 ◽  
Author(s):  
A Drzewiecka ◽  
K Urbańska ◽  
Z Matuszak ◽  
M Pineiro ◽  
L G Arnaut ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
Biological Effect ◽  
Photophysical Properties ◽  
Red Light ◽  
Human Melanoma ◽  
Oxygen Production ◽  
Absorption And Emission ◽  
Emission Properties

We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off < 630 nm). The surviving fraction of the cells decreased about 3-fold (vs. non-irradiated cells) for an 81 J/cm dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.

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